BIOPEP-UWM: Peptide Data
ID
Name
Sequence
CNGKRVCVCG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)O InChI=1S/C39H71N15O12S3/c1-18(2)29(38(66)52-25(17-69)36(64)54-30(19(3)4)37(65)51-24(16-68)33(61)47-14-28(57)58)53-35(63)22(9-7-11-45-39(43)44)49-34(62)21(8-5-6-10-40)48-27(56)13-46-32(60)23(12-26(42)55)50-31(59)20(41)15-67/h18-25,29-30,67-69H,5-17,40-41H2,1-4H3,(H2,42,55)(H,46,60)(H,47,61)(H,48,56)(H,49,62)(H,50,59)(H,51,65)(H,52,66)(H,53,63)(H,54,64)(H,57,58)(H4,43,44,45)/t20-,21-,22-,23-,24-,25-,29-,30-/m0/s1 InChIKey: SNVCMGBTEIZYDM-AEXQHHOOSA-N This fragment shows activity against fungi and G(+) bacteria. The active form of this fragment is C-terminal amide, so Gly was added. Peptide is the precursor of antibacterial peptide (ID 2583 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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