BIOPEP-UWM: Peptide Data
ID
Name
Sequence
YCNGKRVCVCRG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O InChI=1S/C54H92N20O15S3/c1-26(2)41(51(88)72-37(25-92)50(87)74-42(27(3)4)52(89)71-36(24-91)48(85)67-31(10-7-17-62-53(58)59)44(81)65-22-40(78)79)73-47(84)33(11-8-18-63-54(60)61)68-46(83)32(9-5-6-16-55)66-39(77)21-64-45(82)34(20-38(57)76)69-49(86)35(23-90)70-43(80)30(56)19-28-12-14-29(75)15-13-28/h12-15,26-27,30-37,41-42,75,90-92H,5-11,16-25,55-56H2,1-4H3,(H2,57,76)(H,64,82)(H,65,81)(H,66,77)(H,67,85)(H,68,83)(H,69,86)(H,70,80)(H,71,89)(H,72,88)(H,73,84)(H,74,87)(H,78,79)(H4,58,59,62)(H4,60,61,63)/t30-,31-,32-,33-,34-,35-,36-,37-,41-,42-/m0/s1 InChIKey: RUROHZUZDWTCGF-NCSFRLIPSA-N This fragment shows activity against fungi and G(+) bacteria. The active form of this fragment is C-terminal amide, so Gly was added. Peptide is the precursor of antibacterial peptide (ID 2586 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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