BIOPEP-UWM: Peptide Data
ID
Name
Sequence
YCNGKRVCVCG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)NCC(=O)O InChI=1S/C48H80N16O14S3/c1-23(2)37(47(78)62-33(22-81)45(76)64-38(24(3)4)46(77)61-31(20-79)41(72)56-19-36(68)69)63-43(74)29(9-7-15-54-48(52)53)58-42(73)28(8-5-6-14-49)57-35(67)18-55-40(71)30(17-34(51)66)59-44(75)32(21-80)60-39(70)27(50)16-25-10-12-26(65)13-11-25/h10-13,23-24,27-33,37-38,65,79-81H,5-9,14-22,49-50H2,1-4H3,(H2,51,66)(H,55,71)(H,56,72)(H,57,67)(H,58,73)(H,59,75)(H,60,70)(H,61,77)(H,62,78)(H,63,74)(H,64,76)(H,68,69)(H4,52,53,54)/t27-,28-,29-,30-,31-,32-,33-,37-,38-/m0/s1 InChIKey: SMWHRRSGVSESRI-QTQVGGIESA-N This fragment shows activity against fungi and G(+) bacteria. The active form of this fragment is C-terminal amide, so Gly was added. Peptide is the precursor of antibacterial peptide (ID 2587 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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