BIOPEP-UWM: Peptide Data
ID
Name
Sequence
VTCDILSVEAKGVKLG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(N[C@](C(NCC(N[C@](C(N[C@](C(N[C@](C(NCC(O)=O)=O)(CC(C)C)[H])=O)(CCCCN)[H])=O)(C(C)C)[H])=O)=O)(CCCCN)[H])=O)(C)[H])=O)(CCC(O)=O)[H])=O)(C(C)C)[H])=O)(CO)[H])=O)(CC(C)C)[H])=O)([C@@H](C)CC)[H])=O)(CC(O)=O)[H])=O)(CS)[H])=O)([C@@H](C)O)[H])=O)(C(C)C)[H] InChI=1S/C71H126N18O23S/c1-15-38(12)56(88-64(105)46(28-51(95)96)82-66(107)48(32-113)85-71(112)57(40(14)91)89-67(108)53(74)35(6)7)70(111)83-45(27-34(4)5)63(104)84-47(31-90)65(106)87-55(37(10)11)69(110)80-43(22-23-50(93)94)61(102)77-39(13)58(99)78-41(20-16-18-24-72)59(100)75-29-49(92)86-54(36(8)9)68(109)79-42(21-17-19-25-73)62(103)81-44(26-33(2)3)60(101)76-30-52(97)98/h33-48,53-57,90-91,113H,15-32,72-74H2,1-14H3,(H,75,100)(H,76,101)(H,77,102)(H,78,99)(H,79,109)(H,80,110)(H,81,103)(H,82,107)(H,83,111)(H,84,104)(H,85,112)(H,86,92)(H,87,106)(H,88,105)(H,89,108)(H,93,94)(H,95,96)(H,97,98)/t38-,39-,40+,41-,42-,43-,44-,45-,46-,47-,48-,53-,54-,55-,56-,57-/m0/s1 InChIKey: RRGUAPNCQQPSTG-FVPCKDGLSA-N This fragment shows activity against fungi and G(+) bacteria. The active form of this fragment is C-terminal amide, so Gly was added. Peptide is the precursor of antibacterial peptide (ID 2594 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
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