BIOPEP-UWM: Peptide Data
ID
Name
Sequence
HLPLP
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1cnc[nH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C28H45N7O6/c1-16(2)11-20(32-24(36)19(29)13-18-14-30-15-31-18)26(38)34-9-5-7-22(34)25(37)33-21(12-17(3)4)27(39)35-10-6-8-23(35)28(40)41/h14-17,19-23H,5-13,29H2,1-4H3,(H,30,31)(H,32,36)(H,33,37)(H,40,41)/t19-,20-,21-,22-,23-/m0/s1 InChIKey: FGQVFEKPNYGHEX-VUBDRERZSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001 Another value of peptide IC50 (EC50) = 21 uM. Hernández-Ledesma B., Quirós A., Amigo L., Recio I., 2007, Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin. Int. Dairy J., 17, 42-49 Antihypertensive activity in vivo in rats: Sanchez-Rivera L., Ferreira Santos P., Miralles B., Carron R., Montero J., Recio I., 2016, Peptide fragments from beta-casein f(134–138), HLPLP, generated by the action of rat blood plasma peptidases show potent antihypertensive activity. Food Res. Int., 88, 348-353
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