BIOPEP-UWM: Peptide Data
ID
Name
Sequence
RRWCFRVCYRGFCYRKCRG
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(O)=O InChI=1S/C110H167N39O22S4/c1-59(2)87(149-94(161)75(31-18-46-130-110(123)124)140-97(164)77(48-61-21-7-4-8-22-61)141-102(169)83(57-174)147-99(166)80(51-64-52-131-69-25-10-9-23-67(64)69)144-92(159)73(29-16-44-128-108(119)120)135-88(155)68(112)24-13-41-125-105(113)114)104(171)148-84(58-175)103(170)143-78(49-62-32-36-65(150)37-33-62)96(163)136-70(27-14-42-126-106(115)116)89(156)132-53-85(152)134-76(47-60-19-5-3-6-20-60)95(162)146-82(56-173)101(168)142-79(50-63-34-38-66(151)39-35-63)98(165)139-74(30-17-45-129-109(121)122)91(158)138-72(26-11-12-40-111)93(160)145-81(55-172)100(167)137-71(28-15-43-127-107(117)118)90(157)133-54-86(153)154/h3-10,19-23,25,32-39,52,59,68,70-84,87,131,150-151,172-175H,11-18,24,26-31,40-51,53-58,111-112H2,1-2H3,(H,132,156)(H,133,157)(H,134,152)(H,135,155)(H,136,163)(H,137,167)(H,138,158)(H,139,165)(H,140,164)(H,141,169)(H,142,168)(H,143,170)(H,144,159)(H,145,160)(H,146,162)(H,147,166)(H,148,171)(H,149,161)(H,153,154)(H4,113,114,125)(H4,115,116,126)(H4,117,118,127)(H4,119,120,128)(H4,121,122,129)(H4,123,124,130)/t68-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,87-/m0/s1 InChIKey=QBNZKDCJRNEYAH-NYDHICMPSA-N Gly was added at C-terminus, because the active form of this peptide is C-terminal amide. This peptide is active against G(+) and G(-) bacteria.BBA 1197,109-131(1994). Peptide is the precursor of polyphemusin I (ID 2794 in BIOPEP-UWM database of bioactive peptides). Reviews concerning C-terminal amidation of peptides: Bradbury A. F., Smyth D. G., 1991, Peptide amidation. Trends Biochem. Sci., 16, 112-115 Merkler D. J., 1994, C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity. Enzyme Microb. Technol., 16, 450-456
activity
references
function information
database references
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list of peptides