BIOPEP-UWM: Peptide Data
ID
Name
Sequence
IPI
Chemical Mass
Number of residues
Monoisotopic Mass
EC50
IC50
µM
Additional Information
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)[C@H](CC)C)CCC1)[C@H](CC)C InChI=1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1 InChIKey=JNTMAZFVYNDPLB-PEDHHIEDSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: S09.003 Another measured value of IC50 (EC50) of peptide is 3.50 um (Leiting B., Pryor K. D., Wu J. K., Marsilio F., Patel R. A., Craik C. S., Ellman J. A., Cummings R. T., Thornberry N. A., 2003, Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. Biochem. J., 371, 525-532) and 4.23 um (Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653). Another references concerning peptide: Lacroix I. M. E., Li-Chan E. C. Y., 2012, Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422 Nongonierma A. B., FitzGerald R. J., 2013, Inhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides. J. Funct. Foods, 5, 1909-1917 Davy A., Thomsen K. K., Juliano M. A., Alves L. C., Svendsen I., Simpson D. J., Purification and characterization of barley dipeptidyl peptidase IV. Plant Physiology, 122, 425-431 (2000). Inhibitor of tripeptidyl aminopeptidase (MEROPS ID: S08.A56) according to the ChEMBL database Inhibitor of Tripeptidyl peptidase 2 (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database
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