BIOPEP-UWM: Report

ID 10087
Name Hypotensive peptide
sequence
IPIPATKT
Function:
Peptide lowering blood pressure in rats and mice
 
Number of residues
8
Activity code
hyp
Activity :
hypotensive
Chemical mass 840.0161 Monoisotopic mass 839.5100
IC50 :
64.00 µM


Bibliographic data:
Authors
Chen M., Pan D., Zhou T., Gao X., Dang Y.
Title
Novel umami peptide IPIPATKT with dual dipeptidyl peptidase-IV and angiotensin I-converting enzyme inhibitory activities. J. Agric. Food Chem., 69, 5463–5470, 2021
Year Source
2021 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES:
N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O

InChI=1S/C39H69N9O11/c1-8-20(3)28(41)37(56)47-18-12-16-27(47)35(54)44-29(21(4)9-2)38(57)48-19-13-15-26(48)34(53)42-22(5)32(51)45-30(23(6)49)36(55)43-25(14-10-11-17-40)33(52)46-31(24(7)50)39(58)59/h20-31,49-50H,8-19,40-41H2,1-7H3,(H,42,53)(H,43,55)(H,44,54)(H,45,51)(H,46,52)(H,58,59)/t20-,21-,22-,23+,24+,25-,26-,27-,28-,29-,30-,31-/m0/s1

InChIKey=DJBAMXWCFJUMDI-APUFCKIISA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 10085)
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5; MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 10086)


Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 497)


Database reference:
BIOPEP-UWM database of bioactive peptides: ID 10085; 10086

BIOPEP-UWM database of sensory peptides and amino acids: ID 497