BIOPEP-UWM: Report

ID 10124
Name Soybean lunasin immunomodulating peptide
sequence
SKWQHQQDSCRKQLQGVNLTPCEKHIMEKIQGRGDDDDDDDDD
Function:
Immunomodulating
 
Number of residues
43
Activity code
im
Activity :
immunomodulating
Chemical mass 5028.3057 Monoisotopic mass 5025.2238
EC50 :
0.00 µM


Bibliographic data:
Authors
Fernández-Tomé S., Indiano-Romacho P., Mora-Gutiérrez I., Pérez-Rodríguez L., Ortega Moreno L., Marin A. C., Baldán-Martín M., Moreno-Monteagudo J. A.
Title
Lunasin peptide is a modulator of the immune response in the human gastrointestinal tract. Mol. Nutr. Food Res., 65, 2001034, 2021
Year Source
2021 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC5=C[N]([H])C=N5)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O

InChI=1S/C204H321N65O78S3/c1-13-93(9)160(199(343)245-109(38-46-138(211)274)166(310)227-81-144(280)231-102(34-25-58-223-203(217)218)164(308)226-82-145(281)232-123(68-149(287)288)183(327)253-124(69-150(289)290)184(328)254-125(70-151(291)292)185(329)255-126(71-152(293)294)186(330)256-127(72-153(295)296)187(331)257-128(73-154(297)298)188(332)258-129(74-155(299)300)189(333)259-130(75-156(301)302)190(334)261-132(202(346)347)77-158(305)306)266-178(322)106(33-20-24-57-208)236-172(316)114(43-51-147(283)284)241-177(321)116(53-61-350-12)246-200(344)161(94(10)14-2)267-193(337)121(66-98-80-222-89-230-98)251-170(314)105(32-19-23-56-207)235-173(317)115(44-52-148(285)286)244-196(340)135(87-349)264-197(341)136-36-27-60-269(136)201(345)162(95(11)272)268-192(336)118(63-91(5)6)248-182(326)122(67-143(216)279)260-198(342)159(92(7)8)265-146(282)83-228-165(309)108(37-45-137(210)273)238-179(323)117(62-90(3)4)247-174(318)111(40-48-140(213)276)239-167(311)104(31-18-22-55-206)234-168(312)107(35-26-59-224-204(219)220)237-195(339)134(86-348)263-194(338)133(85-271)262-191(335)131(76-157(303)304)252-176(320)112(41-49-141(214)277)240-171(315)110(39-47-139(212)275)243-181(325)120(65-97-79-221-88-229-97)250-175(319)113(42-50-142(215)278)242-180(324)119(64-96-78-225-101-29-16-15-28-99(96)101)249-169(313)103(30-17-21-54-205)233-163(307)100(209)84-270/h15-16,28-29,78-80,88-95,100,102-136,159-162,225,270-272,348-349H,13-14,17-27,30-77,81-87,205-209H2,1-12H3,(H2,210,273)(H2,211,274)(H2,212,275)(H2,213,276)(H2,214,277)(H2,215,278)(H2,216,279)(H,221,229)(H,222,230)(H,226,308)(H,227,310)(H,228,309)(H,231,280)(H,232,281)(H,233,307)(H,234,312)(H,235,317)(H,236,316)(H,237,339)(H,238,323)(H,239,311)(H,240,315)(H,241,321)(H,242,324)(H,243,325)(H,244,340)(H,245,343)(H,246,344)(H,247,318)(H,248,326)(H,249,313)(H,250,319)(H,251,314)(H,252,320)(H,253,327)(H,254,328)(H,255,329)(H,256,330)(H,257,331)(H,258,332)(H,259,333)(H,260,342)(H,261,334)(H,262,335)(H,263,338)(H,264,341)(H,265,282)(H,266,322)(H,267,337)(H,268,336)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H,303,304)(H,305,306)(H,346,347)(H4,217,218,223)(H4,219,220,224)/t93-,94-,95+,100-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,159-,160-,161-,162-/m0/s1

InChIKey=GXMLUULMDUFVAH-ASPFZTNWSA-N


Review concerning Lunasin:
Hsieh C.-C., Martínez-Villaluenga C., de Lumen B. O., Hernández-Ledesma B., 2018, Updating the research on the chemopreventive and therapeutic role of the peptide lunasin. J. Sci. Food Agric., 98, 2070–2079


Anticancer peptide according to the APD database; the BIOPEP-UWM database of bioactive peptides (ID 9525); the EROP-Moscow database
Anti inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9525)


Database reference:
APD: ID AP02329

BIOPEP-UWM database of bioactive peptides: ID 9525, 9526

EROP-Moscow: ID E01558