BIOPEP-UWM: Report

ID 10134
Name Rapakinin – hypotensive peptide
sequence
RIY

Function:
Peptide dilating mesenteric artery in rats
 
Number of residues
3
Activity code
hyp
Activity :
hypotensive
Chemical mass 450.5305 Monoisotopic mass 450.2583
EC50 :
0.00 µM



Bibliographic data:
Authors
Yamada Y., Iwasaki M., Usui H., Ohinata K., Marczak E. D., Lipkowski A. W., Yoshikawa M.
Title
Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK1 receptor. Peptides, 31, 909–914, 2010
Year Source
2010 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C21H34N6O5/c1-3-12(2)17(27-18(29)15(22)5-4-10-25-21(23)24)19(30)26-16(20(31)32)11-13-6-8-14(28)9-7-13/h6-9,12,15-17,28H,3-5,10-11,22H2,1-2H3,(H,26,30)(H,27,29)(H,31,32)(H4,23,24,25)/t12-,15-,16-,17-/m0/s1

InChIKey=FNXCAFKDGBROCU-STECZYCISA-N


Appetite regulating (anorexigenic) peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10135
Opioid antagonist according to the BIOPEP-UWM database of bioactive peptides (ID 10133)
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 7821); the EROP-Moscow database



Database reference:
AHTPDB: ID 1569, 1949, 2957, 4247, 4754, 4982, 5114, 5247, 6142, 6724

BIOPEP-UWM database of bioactive peptides: ID 7821; 10133; 10135

ChEBI: ID 159074

ChemSpider: ID 8000749

EPA DSSTox: ID DTXSID50431365

EROP-Moscow: ID E05001

FeptideDB: ID 7821

J-GLOBAL: ID 200907091912921056

MeSH: term arginyl-isoleucyl-tyrosine; ID C514605

Nikkaji: ID J1.911.456B

PubChem: CID 9825002

SATPdb: ID satpdb16973