BIOPEP-UWM: Report

ID 10162
Name HMG-CoA reductase inhibitor
sequence
YDFYPSSTKDQQS
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
13
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 1565.5883 Monoisotopic mass 1564.6658
EC50 :
0.00 µM


Bibliographic data:
Authors
Lammi C., Zanoni C., Arnoldi A., Aiello G.
Title
YDFYPSSTKDQQS (P3), a peptide from lupin protein, absorbed by Caco-2 cells, modulates cholesterol metabolism in HepG2 cells via SREBP-1 activation. J. Food Biochem., 42, e12524, 2018
Year Source
2018 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CO)C(=O)O

InChI=1S/C69H96N16O26/c1-34(89)56(67(108)76-41(10-5-6-24-70)58(99)79-46(30-55(96)97)62(103)75-42(20-22-52(72)92)59(100)74-43(21-23-53(73)93)60(101)83-50(33-88)69(110)111)84-65(106)49(32-87)81-64(105)48(31-86)82-66(107)51-11-7-25-85(51)68(109)47(28-37-14-18-39(91)19-15-37)80-61(102)44(27-35-8-3-2-4-9-35)78-63(104)45(29-54(94)95)77-57(98)40(71)26-36-12-16-38(90)17-13-36/h2-4,8-9,12-19,34,40-51,56,86-91H,5-7,10-11,20-33,70-71H2,1H3,(H2,72,92)(H2,73,93)(H,74,100)(H,75,103)(H,76,108)(H,77,98)(H,78,104)(H,79,99)(H,80,102)(H,81,105)(H,82,107)(H,83,101)(H,84,106)(H,94,95)(H,96,97)(H,110,111)/t34-,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51+,56+/m1/s1

InChIKey=RWANIDSEAFDRFG-QQHFLRTMSA-N


HMG-CoA reductase (EC 1.1.1.34) is involved in cholesterol biosynthesis


Database reference: