BIOPEP-UWM: Report

ID 10171
Name Neurolysin inhibitor
sequence
RP
Function:
Inhibitor of the neurolysin (EC 3.4.24.16) (MEROPS ID: M03.002)
 
Number of residues
2
Activity code
neul
Activity :
neurolysin inhibitor
Chemical mass 271.3153 Monoisotopic mass 271.1640
EC50 :
0.00 µM


Bibliographic data:
Authors
Dahms P., Mentlein R.
Title
Purification of the main somatostatin-degrading proteases from rat and pig brains, their action on other neuropeptides, and their identification as endopeptidases 24.15 and 24.16. Eur. J. Biochem., 208, 145-154, 1992
Year Source
1992 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCN=C(N)N)N)C(=O)O

InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1

InChIKey: LQJAALCCPOTJGB-YUMQZZPRSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
Antinociceptive activity according to the ChEMBL database; the PubChem database
Affinity to neurotensin receptor according to the BIOPEP-UWM database (ID 10116); ChEMBL database; the PubChem database
Antiviral peptide according to the AVPdb database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8518)
Inhibitor of angiotensin-converting enzyme according to the AHTPDB database, the BIOPEP database of bioactive peptides (ID 7582), the ChEMBL database; the EROP-Moscow database

Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 11)
Salty taste enhancing peptide according to the BIOPEP database of sensory peptides and amino acids (ID 419)


Database reference:
ACToR: ID 2418-69-1

AHTPDB: ID 1120; 1390; 1470; 1502; 2793; 3054; 3056; 3083; 3179; 3221; 3533; 3583; 3789; 4021; 4442; 4495; 4676; 5423; 5452; 5641; 5676; 6114; 6568

AVPdb: ID AVP1054

BIOPEP database of bioactive peptides: ID 7582; 8518; 10116

BIOPEP database of sensory peptides and amino acids: ID 11; 419

BRENDA: Ligand Arg-Pro

ChEMBL: ID CHEMBL48223

ChemIDplus: ID 002418691

ChemSpider: ID 133095

EROP-Moscow: ID E10402

PubChem: ID 151003

SATPdb: ID satpdb23927

ZINC: ID ZINC04899739