BIOPEP-UWM: Report

ID 10211
Name Acetylcholinesterase inhibitor
sequence
RMLRTTRY

Function:
Inhibitor of Acetylcholinesterase (EC 3.1.1.7)
 
Number of residues
8
Activity code
ache
Activity :
AChE inhibitor
Chemical mass 1096.3049 Monoisotopic mass 1095.5954
IC50 :
102.20 µM



Bibliographic data:
Authors
Dastan D., Zhiyani R., Fasihi K., Ebadi A.
Title
An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis and biological evaluation. J. Mol. Model., 28, 86, 2022
Year Source
2022 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C46H81N17O12S/c1-23(2)21-32(60-38(69)31(16-20-76-5)57-36(67)28(47)9-6-17-54-44(48)49)40(71)58-30(11-8-19-56-46(52)53)39(70)62-35(25(4)65)42(73)63-34(24(3)64)41(72)59-29(10-7-18-55-45(50)51)37(68)61-33(43(74)75)22-26-12-14-27(66)15-13-26/h12-15,23-25,28-35,64-66H,6-11,16-22,47H2,1-5H3,(H,57,67)(H,58,71)(H,59,72)(H,60,69)(H,61,68)(H,62,70)(H,63,73)(H,74,75)(H4,48,49,54)(H4,50,51,55)(H4,52,53,56)/t24-,25-,28+,29+,30+,31+,32+,33+,34+,35+/m1/s1

InChIKey=SGRJNCAHFCPLPL-QFTRKFIISA-N



Database reference: