BIOPEP-UWM: Report

ID 10237
Name HMG-CoA reductase inhibitor
sequence
QDF
Function:
Inhibitor of HMG-CoA reductase (EC 1.1.1.34)
 
Number of residues
3
Activity code
HMGi
Activity :
HMG-CoA reductase inhibitor
Chemical mass 408.4048 Monoisotopic mass 408.1639
IC50 :
12.80 µM


Bibliographic data:
Authors
Silva M. B. C. E., Souza C. A. D. C., Philadelpho B. O., Cunha M. M. N. D., Batista F. P. R., Silva J. R. D., Druzian J. I., Castilho M. S., Cilli E.
Title
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide. Food Chem., 259, 270-277, 2018
Year Source
2018 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C18H24N4O7/c19-11(6-7-14(20)23)16(26)21-12(9-15(24)25)17(27)22-13(18(28)29)8-10-4-2-1-3-5-10/h1-5,11-13H,6-9,19H2,(H2,20,23)(H,21,26)(H,22,27)(H,24,25)(H,28,29)/t11-,12-,13-/m0/s1

InChIKey=JKPGHIQCHIIRMS-AVGNSLFASA-N


Database reference:
ChEBI: ID 162007

EROP-Moscow: ID E24166

PubChem: CID 145455011