BIOPEP-UWM: Report

ID 10256
Name Hypotensive peptide
sequence
HPHPHLSF
Function:
Lowering blood pressure in rats
 
Number of residues
8
Activity code
hyp
Activity :
hypotensive
Chemical mass 971.0698 Monoisotopic mass 970.4760
EC50 :
0.00 µM


Bibliographic data:
Authors
Miguel M., Gómez-Ruiz J. Á., Recio I., Aleixandre A.
Title
Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats. Mol. Nutr. Food Res., 54, 1422-1447, 2010
Year Source
2010 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C46H62N14O10/c1-26(2)14-32(39(62)58-36(22-61)41(64)57-35(46(69)70)15-27-8-4-3-5-9-27)54-40(63)33(17-29-20-49-24-52-29)55-42(65)38-11-7-13-60(38)45(68)34(18-30-21-50-25-53-30)56-43(66)37-10-6-12-59(37)44(67)31(47)16-28-19-48-23-51-28/h3-5,8-9,19-21,23-26,31-38,61H,6-7,10-18,22,47H2,1-2H3,(H,48,51)(H,49,52)(H,50,53)(H,54,63)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1

InChIKey=CAUGYGWAFDJIGN-QSVFAHTRSA-N


Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10251); the MBPDB database
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 10255); the DFBP database; the MBPDB database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10254; the DFBP database


Database reference:
AHTPDB: ID 1736, 4156, 4190, 5035

BioPepDB: ID biopep00469

BIOPEP-UWM database of bioactive peptides: ID 10251; 10254; 10255

DFBP: ID DFBPACEI1466; DFBPANHY0968; DFBPANOX0258; DFBPMUFU0397

EROP-Moscow: ID E14759

J-GLOBAL: ID 200907085393914110

MBPDB: peptide HPHPHLSF

Nikkaji: ID J2.666.949I

PubChem: CID 102027191

SATPdb: ID satpdb21333