BIOPEP-UWM: Report

ID 10431
Name Chemotactic peptide
sequence
WKYMVm
Function:
Agonist of FPR1 and FPR3 receptors
 
Number of residues
6
Activity code
che
Activity :
chemotactic
Chemical mass 857.0937 Monoisotopic mass 856.3962
EC50 :
0.00 µM


Bibliographic data:
Authors
Christophe T., Karlsson A., Dugave C., Rabiet M. J., Boulay F., Dahlgren C.
Title
The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J. Biol. Chem., 276, 21585-21593, 2001
Year Source
2021 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@]([H])(CCSC)C(=O)O

InChI=1S/C41H60N8O8S2/c1-24(2)35(40(55)47-33(41(56)57)17-20-59-4)49-38(53)32(16-19-58-3)46-39(54)34(21-25-12-14-27(50)15-13-25)48-37(52)31(11-7-8-18-42)45-36(51)29(43)22-26-23-44-30-10-6-5-9-28(26)30/h5-6,9-10,12-15,23-24,29,31-35,44,50H,7-8,11,16-22,42-43H2,1-4H3,(H,45,51)(H,46,54)(H,47,55)(H,48,52)(H,49,53)(H,56,57)/t29-,31-,32-,33+,34-,35-/m0/s1

InChIKey=VQBTUIJFUPRJOH-RSQZODEZSA-N


Review: Prevete N., Liotti F., Marone G., Melillo R. M., de Paulis A., 2015, Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth. Pharmacol. Res., 102, 184–191


Database reference:
CAS: Registry No 211868-45-0

ChEMBL: ID CHEMBL2336645

EPA CompTox: ID DTXSID10332420

IUPHAR/BPS: GtoPdb Ligand ID 1048

J-GLOBAL: ID 200907034796335787

Nikkaji: ID J1.473.123G

PubChem: CID 456181