BIOPEP-UWM: Report

ID 10433
Name Chemotactic peptide
sequence
{C1}MIFL

Function:
Agonist of FPR1 receptor
 
Number of residues
5
Activity code
che
Activity :
chemotactic
Chemical mass 550.7100 Monoisotopic mass 550.2815
EC50 :
0.00 µM



Bibliographic data:
Authors
Rot A., Henderson L. E., Copeland T. D., Leonard E. J.
Title
A series of six ligands for the human formyl peptide receptor: tetrapeptides with high chemotactic potency and efficacy. Proc. Natl Acad. Sci. USA, 84, 7967-7971, 1987
Year Source
1987 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C27H42N4O6S/c1-6-18(4)23(31-24(33)20(28-16-32)12-13-38-5)26(35)29-21(15-19-10-8-7-9-11-19)25(34)30-22(27(36)37)14-17(2)3/h7-11,16-18,20-23H,6,12-15H2,1-5H3,(H,28,32)(H,29,35)(H,30,34)(H,31,33)(H,36,37)/t18-,20-,21-,22-,23-/m0/s1

InChIKey=AYHNUZYRPSGLMJ-SVXFZJLFSA-N


{C1} - Formic acid – N-terminal modification (BIOPEP-UWM repository of amino acids and modifications: ID 157)

Review: Prevete N., Liotti F., Marone G., Melillo R. M., de Paulis A., 2015, Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth. Pharmacol. Res., 102, 184–191



Database reference:
IUPHAR/BPS: GtoPdb Ligand ID 1021

J-Global: ID J-GLOBAL ID:200907076245098002

Nikkaji: ID J705.115H

PubChem: CID 10030470