BIOPEP-UWM: Report

ID 10434
Name Chemotactic peptide
sequence
{C1}MMWLL

Function:
Agonist of FPR1 receptor
 
Number of residues
6
Activity code
che
Activity :
chemotactic
Chemical mass 720.9428 Monoisotopic mass 720.3327
EC50 :
0.00 µM



Bibliographic data:
Authors
Chen J., Bernstein H. S., Chen M., Wang L., Ishii M., Turck C. W., Coughlin S. R.
Title
Tethered ligand library for discovery of peptide agonists. J. Biol. Chem., 270, 23398-23401, 1995
Year Source
1995 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C34H52N6O7S2/c1-20(2)15-27(32(44)40-29(34(46)47)16-21(3)4)38-33(45)28(17-22-18-35-24-10-8-7-9-23(22)24)39-31(43)26(12-14-49-6)37-30(42)25(36-19-41)11-13-48-5/h7-10,18-21,25-29,35H,11-17H2,1-6H3,(H,36,41)(H,37,42)(H,38,45)(H,39,43)(H,40,44)(H,46,47)/t25-,26-,27-,28-,29-/m0/s1

InChIKey=JGNCAZDTORSPSW-ZIUUJSQJSA-N


{C1} - Formic acid – N-terminal modification (BIOPEP-UWM repository of amino acids and modifications: ID 157)

Review: Prevete N., Liotti F., Marone G., Melillo R. M., de Paulis A., 2015, Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth. Pharmacol. Res., 102, 184–191



Database reference:
IUPHAR/BPS: GtoPdb Ligand ID 5837