BIOPEP-UWM: Report

ID 10437
Name Chemotactic peptide
sequence
{C1}MMYALF

Function:
Agonist of FPR1 receptor
 
Number of residues
7
Activity code
che
Activity :
chemotactic
Chemical mass 803.0002 Monoisotopic mass 802.3381
EC50 :
0.00 µM



Bibliographic data:
Authors
Rabiet M. J., Huet E., Boulay F.
Title
Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur. J. Immunol., 35, 2486-2495, 2005
Year Source
2005 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C38H54N6O9S2/c1-23(2)19-30(37(51)44-32(38(52)53)21-25-9-7-6-8-10-25)42-33(47)24(3)40-36(50)31(20-26-11-13-27(46)14-12-26)43-35(49)29(16-18-55-5)41-34(48)28(39-22-45)15-17-54-4/h6-14,22-24,28-32,46H,15-21H2,1-5H3,(H,39,45)(H,40,50)(H,41,48)(H,42,47)(H,43,49)(H,44,51)(H,52,53)/t24-,28-,29-,30-,31-,32-/m0/s1

InChIKey=ZCYVFKIIQIAACQ-KNIQQNQGSA-N


{C1} - Formic acid – N-terminal modification (BIOPEP-UWM repository of amino acids and modifications: ID 157)

Review: Prevete N., Liotti F., Marone G., Melillo R. M., de Paulis A., 2015, Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth. Pharmacol. Res., 102, 184–191



Database reference:
IUPHAR/BPS: GtoPdb Ligand ID 1023