BIOPEP-UWM: Report

ID 10442
Name Cyclooxygenase-1 inhibitor
sequence
AIPAAPAAPAGPKLY
Function:
Inhibitor of cyclooxygenase-1 (EC 1.14.99.1)
 
Number of residues
15
Activity code
cox1
Activity :
cyclooxygenase-1 inhibitor
Chemical mass 1407.6513 Monoisotopic mass 1406.7897
IC50 :
0.16 µM


Bibliographic data:
Authors
Hayes M., Aluko R. E., Aurino E., Mora L.
Title
Generation of bioactive peptides from Porphyridium sp. and assessment of their potential for Use in the prevention of hypertension, inflammation and pain. Marine Drugs, 21, 422, 2023
Year Source
2023 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C67H106N16O17/c1-11-36(4)53(79-54(86)37(5)69)66(98)83-31-17-22-51(83)62(94)73-40(8)57(89)75-42(10)65(97)82-30-16-21-50(82)61(93)72-39(7)56(88)74-41(9)64(96)81-29-15-20-49(81)60(92)71-38(6)55(87)70-34-52(85)80-28-14-19-48(80)63(95)76-45(18-12-13-27-68)58(90)77-46(32-35(2)3)59(91)78-47(67(99)100)33-43-23-25-44(84)26-24-43/h23-26,35-42,45-51,53,84H,11-22,27-34,68-69H2,1-10H3,(H,70,87)(H,71,92)(H,72,93)(H,73,94)(H,74,88)(H,75,89)(H,76,95)(H,77,90)(H,78,91)(H,79,86)(H,99,100)/t36-,37-,38-,39-,40-,41-,42-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1

InChIKey=HJIJGRHOBHIJJD-VXBMVYAYSA-N


Database reference: