BIOPEP-UWM: Report

ID 10443
Name Cyclooxygenase-1 inhibitor
sequence
LIHADPPGVGL
Function:
Inhibitor of cyclooxygenase-1 (EC 1.14.99.1)
 
Number of residues
11
Activity code
cox1
Activity :
cyclooxygenase-1 inhibitor
Chemical mass 1088.2536 Monoisotopic mass 1087.6007
IC50 :
0.20 µM


Bibliographic data:
Authors
Hayes M., Aluko R. E., Aurino E., Mora L.
Title
Generation of bioactive peptides from Porphyridium sp. and assessment of their potential for Use in the prevention of hypertension, inflammation and pain. Marine Drugs, 21, 422, 2023
Year Source
2023 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)O

InChI=1S/C50H81N13O14/c1-10-28(8)41(61-43(69)31(51)17-25(2)3)47(73)58-32(19-30-21-52-24-55-30)44(70)56-29(9)42(68)59-33(20-39(66)67)48(74)63-16-12-14-36(63)49(75)62-15-11-13-35(62)45(71)53-23-38(65)60-40(27(6)7)46(72)54-22-37(64)57-34(50(76)77)18-26(4)5/h21,24-29,31-36,40-41H,10-20,22-23,51H2,1-9H3,(H,52,55)(H,53,71)(H,54,72)(H,56,70)(H,57,64)(H,58,73)(H,59,68)(H,60,65)(H,61,69)(H,66,67)(H,76,77)/t28-,29-,31-,32-,33-,34-,35-,36-,40-,41-/m0/s1

InChIKey=DCXDTNRFENTJGG-RNEJCJHHSA-N


Database reference: