BIOPEP-UWM: Report

ID 10460
Name ACE2 inhibitor
sequence
PF
Function:
Inhibitor of angiotensin-converting enzyme 2 (EC 3.4.17.23; MEROPS ID: M02.006)
 
Number of residues
2
Activity code
ace2
Activity :
ACE2 inhibitor
Chemical mass 262.3036 Monoisotopic mass 262.1313
IC50 :
150.00 µM


Bibliographic data:
Authors
Guy J. L., Jackson R. M., Acharya K. R., Sturrock E. D., Hooper N. M., Turner A. J.
Title
Angiotensin-converting enzyme-2 (ACE2): comparative modelling of the active site, substrate specificity and chloride dependence. Biochemistry, 42, 13185–13192, 2003
Year Source
2003 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C14H18N2O3/c17-13(11-7-4-8-15-11)16-12(14(18)19)9-10-5-2-1-3-6-10/h1-3,5-6,11-12,15H,4,7-9H2,(H,16,17)(H,18,19)/t11-,12-/m0/s1

InChIKey=IWIANZLCJVYEFX-RYUDHWBXSA-N


Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1; MEROPS ID: M02-001) according to the AHTPDB database
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) the BIOPEP-UWM database of bioactive peptides (ID 8854)
Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9505)


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids; the ChEMBL database; the PubChem database


Database reference:
AHTPDB: ID 3875

BIOPEP-UWM database of bioactive peptides: ID 8854; 9505

BIOPEP-UWM database of sensory peptides and amino acids: ID 55

BRENDA: Ligand Pro-Phe

ChEBI: ID 74795

ChEMBL: ID CHEMBL52922

ChemSpider: ID 4894402

EROP-Moscow: ID E03992

J-GLOBAL: ID 200907023710790183

Metabolights: ID MTBLC74795

Nikkaji: ID J120.395I

PubChem: ID 6351946

SATPdb: ID satpdb18871

SureChEMBL: ID SCHEMBL601567

ZINC: ID ZINC000004038394