BIOPEP-UWM: Report

ID 10493
Name Acetylcholinesterase inhibitor
sequence
PQDER

Function:
Inhibitor of Acetylcholinesterase (EC 3.1.1.7)
 
Number of residues
5
Activity code
ache
Activity :
AChE inhibitor
Chemical mass 643.6451 Monoisotopic mass 643.2916
IC50 :
603.00 µM



Bibliographic data:
Authors
Asen N.D., Okagu O.D., Udenigwe C.C., Aluko R.E.
Title
In vitro inhibition of acetylcholinesterase activity by yellow field pea (Pisum sativum) protein-derived peptides as revealed by kinetics and molecular docking. Front. Nutr., 9, 2022
Year Source
2022 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C25H41N9O11/c26-17(35)7-5-13(31-20(40)12-3-1-9-29-12)22(42)34-16(11-19(38)39)23(43)32-14(6-8-18(36)37)21(41)33-15(24(44)45)4-2-10-30-25(27)28/h12-16,29H,1-11H2,(H2,26,35)(H,31,40)(H,32,43)(H,33,41)(H,34,42)(H,36,37)(H,38,39)(H,44,45)(H4,27,28,30)/t12-,13-,14-,15-,16-/m0/s1

InChIKey=RVAWQBGMGYRXIC-QXKUPLGCSA-N

The IC50 value was calculated in μmol/L.



Database reference: