BIOPEP-UWM: Report

ID 10581
Name ACE inhibitor
sequence
{Thea}{GABA}P
Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
3
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 356.4162 Monoisotopic mass 356.2053
IC50 :
143.54 µM


Bibliographic data:
Authors
Qian B., Tian C., Huo J., Ding Z., Xu R., Zhu J., Yu L., Villarreal O. D.
Title
Design and evaluation of four novel tripeptides as potent angiotensin converting enzyme (ACE) inhibitors with anti-hypertension activity. Peptides, 122, 170171, 2019
Year Source
2019 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(CCC(=O)NCC)C(=O)NCCCC(=O)N1[C@@]([H])(CCC1)C(=O)O

InChI=1S/C16H28N4O5/c1-2-18-13(21)8-7-11(17)15(23)19-9-3-6-14(22)20-10-4-5-12(20)16(24)25/h11-12H,2-10,17H2,1H3,(H,18,21)(H,19,23)(H,24,25)/t11-,12-/m0/s1

InChIKey=UBLAAZCLQXSOSA-RYUDHWBXSA-N

Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/); ID: M02-001


{GABA} - γ-Aminobutyric acid; ID 196 in the BIOPEP-UWM repository of amino acids and modifications
{Thea} - Theanine; ID 208 in the BIOPEP-UWM repository of amino acids and modifications


Database reference: