BIOPEP-UWM: Report

ID 10600
Name Inhibitor of tripeptidyl peptidase II
sequence
GGF
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 279.2911 Monoisotopic mass 279.1215
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O

InChI=1S/C22H31N7O4/c23-15(11-13-12-27-16-6-2-1-5-14(13)16)19(30)28-17(7-3-9-26-22(24)25)20(31)29-10-4-8-18(29)21(32)33/h1-2,5-6,12,15,17-18,27H,3-4,7-11,23H2,(H,28,30)(H,32,33)(H4,24,25,26)/t15-,17-,18-/m0/s1

InChIKey=VIWQOOBRKCGSDK-SZMVWBNQSA-N


Inhibitor of cephradine and cephributen uptake according to the ChEMBL database
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database
Inhibitor of cytosol alanyl aminopeptidase (EC 3.4.11.14) (MEROPS ID: M01.010) according to the BRENDA database


Database reference:
AHTPDB: ID 4555, 4844, 5649

BIOPEP-UWM database of sensory peptides and amino acids: ID 22

BRENDA: Ligand Gly-Gly-Phe

ChEBI: ID 73905

ChEMBL: ID CHEMBL1221711

ChemSpider: ID 5361457

PubChem: CID 6993372

ZINC: ID ZINC01635603