BIOPEP-UWM: Report

ID 10634
Name ACE2 inhibitor
sequence
VPP
Function:
Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006)
 
Number of residues
3
Activity code
ace2
Activity :
ACE2 inhibitor
Chemical mass 311.3757 Monoisotopic mass 311.1839
IC50 :
0.00 µM


Bibliographic data:
Authors
Luhtala S., Vaajanen A., Oksala O., Valjakka J., Vapaatalo H.
Title
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues. J. Ocul. Pharmacol. Ther., 25, 23-28, 2009
Year Source
2009 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@](N)(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O

InChI=1S/C15H25N3O4/c1-9(2)12(16)14(20)17-7-3-5-10(17)13(19)18-8-4-6-11(18)15(21)22/h9-12H,3-8,16H2,1-2H3,(H,21,22)/t10-,11-,12-/m0/s1

InChIKey=DOFAQXCYFQKSHT-SRVKXCTJSA-N


Peptide found also in amaranth protein hydrolysate.

Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111

Review concerning the peptide:
Li S., Bu T., Zheng J., Liu L., He G., Wu J., 2019, Preparation, bioavailability, and mechanism of emerging activities of Ile-Pro-Pro and Val-Pro-Pro. Compr. Rev. Food Sci. Food Saf., 18, 1097-1110


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides (ID 3524); the ChEMBL database; the EROP-Moscow database; the MBPDB database
Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BRENDA database
Anti inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides: ID 9538


Database reference:
AHTPDB: ID 1200, 1275, 1583, 1671, 1711, 2009, 2244, 2740, 2971, 3205, 3403, 3589, 3628, 3735, 3774, 4043, 4122, 4178, 4799, 4963, 4964, 5125, 5262, 5515, 5572, 5629, 6092, 6442

BindingDB: ID 50169128

BioPepDB: ID biopep01435

BIOPEP-UWM database of bioactive peptides: ID 3524, 9538

BRENDA: Ligand Val-Pro-Pro

ChEBI: ID 73696

ChEMBL: ID CHEMBL190414

ChemIdPlus: ID 58872-39-2

ChemSpider: ID 7993950

DFBP: ID DFBPACEI0295, DFBPACEI0342

Drug Information Portal: ID 58872-39-2

EROP-Moscow: ID E07046

FDA SRS: ID 2U1R84870F

J-GLOBAL: ID 200907032217042614

MBPDB: Peptide VPP

Metabolights: ID MTBLC73696

Nikkaji: ID J667.338D

PubChem: CID 9818200

SATPdb: ID satpdb19459

SureChEMBL: ID SCHEMBL1644894

ZINC: ID ZINC000013646338