BIOPEP-UWM: Report

ID 10668
Name Inhibitor of tripeptidyl peptidase II
sequence
{Nle}{Nle}

Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
2
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 244.3296 Monoisotopic mass 244.1781
IC50 :
0.00 µM



Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)O

InChI=1S/C12H24N2O3/c1-3-5-7-9(13)11(15)14-10(12(16)17)8-6-4-2/h9-10H,3-8,13H2,1-2H3,(H,14,15)(H,16,17)/t9-,10-/m0/s1

InChIKey=YWCWRUFTSHXXCO-UWVGGRQHSA-N


{Nle} - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)



Database reference:
BRENDA: Ligand Nle-Nle-OH

CAS: Registry No 114148-92-4

ChEMBL: ID CHEMBL2371256

ChemSpider: ID 30846645

EPA CompTox: ID DTXSID60719368

PubChem: CID 56972312

Wikidata: ID Q82657685