BIOPEP-UWM: Report

ID 10720
Name Neprilysin inhibitor
sequence
FW
Function:
Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.008)
 
Number of residues
2
Activity code
nep
Activity :
neprilysin inhibitor
Chemical mass 351.3982 Monoisotopic mass 351.1578
EC50 :
0.00 µM


Bibliographic data:
Authors
Dion N., Cohen P., Crine P., Boileau G.
Title
Characterisation of neprilysin (EC 3.4.24.11) S2 subsite. FEBS Lett., 411, 140-144, 1997
Year Source
1997 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O

InChI=1S/C15H23N5O3/c16-11(9-10-5-2-1-3-6-10)13(21)20-12(14(22)23)7-4-8-19-15(17)18/h1-3,5-6,11-12H,4,7-9,16H2,(H,20,21)(H,22,23)(H4,17,18,19)/t11-,12-/m0/s1

InChIKey=OZILORBBPKKGRI-RYUDHWBXSA-N


InChI=1S/C20H21N3O3/c21-16(10-13-6-2-1-3-7-13)19(24)23-18(20(25)26)11-14-12-22-17-9-5-4-8-15(14)17/h1-9,12,16,18,22H,10-11,21H2,(H,23,24)(H,25,26)/t16-,18-/m0/s1

InChIKey: JMCOUWKXLXDERB-WMZOPIPTSA-N


Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to AHTPDB database; the BindingDB database; the BIOPEP-UWM database of bioactive peptides; the DFBP database; the PlantPepDB database
Development regulating peptide from hydra according to the EROP-Moscow database
Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides

Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 339); the BitterDB database


Database reference:
AHTPDB: ID 1990; 2005; 2037

BIOPEP-UWM database of sensory peptides and amino acids: ID 339

BitterDB: ID 829

BRENDA: Ligand Phe-Trp

CAS: Registry No 24587-41-5

ChEBI: ID 74751

ChemIDplus: ID 024587415

ChemSpider: ID 118886

DFBP: ID DFBPACEI1985

EPA CompTox: ID DTXSID00947461

EROP-Moscow: ID E02335

FooDB: ID FDB112022

HMDB: ID HMDB0029006

J-GLOBAL: ID 200907074334077539

MeSH: terms Phe-Trp; phenylalanyltryptophan

Metabolomics Workbench: ID 78933

Nikkaji: ID J61.746F

PlantPepDB: ID PPepDB_48

PMhub: ID MS000238150

PubChem: ID 134906

SATPdb: ID satpdb16434

SureChEMBL: ID SCHEMBL2182648

UNII: ID 7G2SCL87C5

ZINC: ID ZINC02575127