BIOPEP-UWM: Report

ID 10754
Name Inhibitor of tripeptidyl peptidase II
sequence
GY
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
2
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 238.2393 Monoisotopic mass 238.0950
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O

InChI=1S/C11H14N2O4/c12-6-10(15)13-9(11(16)17)5-7-1-3-8(14)4-2-7/h1-4,9,14H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1

InChIKey=XBGGUPMXALFZOT-VIFPVBQESA-N


Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8788)
Inhibitor of carboxypeptidase A (EC 3.4.17.1) (MEROPS ID: M14.001) according to the BRENDA database
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02.006) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 3532); the BRENDA database; the ChEMBL database; the PubChem database


Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 32)


Database reference:
AHTPDB: ID 1110; 1140; 1270; 1372; 1380; 1400; 1419; 1809; 1891; 2653; 2746; 2790; 2934; 2980; 3101; 3301; 3496; 3843; 3938; 4075; 4230; 4250; 4251; 4440; 4497; 4682; 5153; 5430; 5591; 5740; 6210; 6450

BindingDB: ID 50188508

BIOPEP-UWM database of bioactive peptides: ID 3532; 8788

BIOPEP-UWM database of sensory peptides and amino acids: ID 32

BRENDA: Ligand Gly-Tyr

CAS: Registry No 658-79-7

ChEBI: ID 73517

ChEMBL: ID CHEMBL53400

ChemSpider ID: 83798

DFBP: ID DFBPACEI1231, DFBPANHY0659, DFBPANHY0951, DFBPANHY0649, DFBPMUFU0266

DrugBank: ID DB15991

EChA: 211-525-1

EPA CompTox: ID DTXSID701316223

EROP-Moscow: ID E09245

FDA SRS: ID A226496H4O

FooDB: ID FDB111885

GSRS: ID f8be4252-ac07-465c-887e-ec15d77e7d6a

HMDB: ID HMDB0028853

J-GLOBAL: ID 200907090094114372

MeSH: Terms Gly-Tyr; glycyl-L-tyrosine

Metabolights: ID MTBLC73517

MMDB: ID 3008.2

Metabolomics Workbench: ID 78814

NIAID: ID 192299, 192300, 192302, 192309

Nikkaji: ID J149.623I

NMRShiftDB: ID 60023651

PLantPepDB: ID PPepDB_2967

ProbesDrugs: ID PD143805

PubChem: CID 92829

SATPdb: ID satpdb13322

SureChEMBL: ID SCHEMBL479126

UNII: ID A226496H4O

VMH: ID GLYTYR

Wikidata: Q27140599

ZINC: ID ZINC01730678