BIOPEP-UWM: Report

ID 10756
Name Inhibitor of tripeptidyl peptidase II
sequence
V{Nle}{~!C1}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 243.3448 Monoisotopic mass 243.1941
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)NC

InChI=1S/C12H25N3O2/c1-5-6-7-9(11(16)14-4)15-12(17)10(13)8(2)3/h8-10H,5-7,13H2,1-4H3,(H,14,16)(H,15,17)/t9-,10-/m0/s1

InChIKey=QHAKKGZIKXJCAK-UWVGGRQHSA-N


{~!C1} - C-terminal aminomethane (ID 131 in the BIOPEP-UWM repository of amino acids and modifications)
{Nle} - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Nle-NHCH3

ChEMBL: ID CHEMBL2371241

ChemSpider: ID 8713601

PubChem: CID 10538210

ZINC: ID ZINC000013805225