BIOPEP-UWM: Report

ID 10757
Name Inhibitor of tripeptidyl peptidase II
sequence
V{Nle}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
2
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 230.3031 Monoisotopic mass 230.1625
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)O

InChI=1S/C11H22N2O3/c1-4-5-6-8(11(15)16)13-10(14)9(12)7(2)3/h7-9H,4-6,12H2,1-3H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1

InChIKey=OYERYTXFSRFVON-IUCAKERBSA-N


{Nle} - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Nle-OH

ChEMBL: ID CHEMBL2371262

ChemSpider: ID30846648

PubChem: CID 73354643