BIOPEP-UWM: Report

ID 10761
Name Inhibitor of tripeptidyl peptidase II
sequence
{C1!}{Nle}{Nle}{~!C1}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
4
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 271.3978 Monoisotopic mass 271.2253
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CN[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)NC

InChI=1S/C14H29N3O2/c1-5-7-9-11(15-3)14(19)17-12(10-8-6-2)13(18)16-4/h11-12,15H,5-10H2,1-4H3,(H,16,18)(H,17,19)/t11-,12-/m0/s1

InChIKey=ZALUYJCLEXKARJ-RYUDHWBXSA-N


{C1!} - N-terminal methyl group (ID 232 in the BIOPEP-UWM repository of amino acids and modifications
{Nle} - Norleucine (ID 231 in the BIOPEP-UWM database of amino acids and modifications)
{!~C1} - Aminomethane as a part of C-terminal amide group (ID 131 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand CH3-Nle-Nle-NHCH3

ChEMBL: ID CHEMBL2371244

ChemSpider: ID 8835097

PubChem: CID 10659743

ZINC: ID ZINC000013805208