BIOPEP-UWM: Report

ID 10762
Name Inhibitor of tripeptidyl peptidase II
sequence
{C2:0}V{Nva}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 258.3132 Monoisotopic mass 258.1574
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCC)C(=O)O

InChI=1S/C12H22N2O4/c1-5-6-9(12(17)18)14-11(16)10(7(2)3)13-8(4)15/h7,9-10H,5-6H2,1-4H3,(H,13,15)(H,14,16)(H,17,18)/t9-,10-/m0/s1

InChIKey=LZROGQHIRWEZML-UWVGGRQHSA-N


{Nva} - Norvaline (ID 230 in the BIOPEP-UWM repository of amino acids and modifications)
{C2:0} - N-terminal acetic acid (ID 130 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand CH3CO-Val-Nvl-OH

ChEMBL: ID CHEMBL2371255

ChemSpider: ID 9024105

PubChem: CID 10848811