BIOPEP-UWM: Report

ID 10763
Name Inhibitor of tripeptidyl peptidase II
sequence
VF{~!C1}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 277.3611 Monoisotopic mass 277.1785
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NC

InChI=1S/C15H23N3O2/c1-10(2)13(16)15(20)18-12(14(19)17-3)9-11-7-5-4-6-8-11/h4-8,10,12-13H,9,16H2,1-3H3,(H,17,19)(H,18,20)/t12-,13-/m0/s1

InChIKey=BGTAIUMSBSLZTL-STQMWFEESA-N


<!~C1> - Aminomethane as a part of C-terminal amide group (ID 131 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Phe-NHCH3

ChEMBL: ID CHEMBL2371253

ChemSpider: ID 8668191

PubChem: CID 10492789

SureChEMBL: ID SCHEMBL7405637

ZINC: ID ZINC000013805240