BIOPEP-UWM: Report

ID 10765
Name Inhibitor of tripeptidyl peptidase II
sequence
{C4:0!}{H2CO3}V{Nle}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
4
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 330.4186 Monoisotopic mass 330.2147
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: CCCCOC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)O

InChI=1S/C16H30N2O5/c1-5-7-9-12(15(20)21)17-14(19)13(11(3)4)18-16(22)23-10-8-6-2/h11-13H,5-10H2,1-4H3,(H,17,19)(H,18,22)(H,20,21)/t12-,13-/m0/s1

InChIKey=WBOPJFBHTDFKKU-STQMWFEESA-N


{C4:0!} - N-terminal butyl group (ID 240 in the BIOPEP-UWM repository of amino acids and modifications)
{H2CO3} - Carbonic acid (ID 228 in the BIOPEP-UWM repository of amino acids and modifications)
{Nle} - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand butyloxycarbonyl-Val-Nle-OH

ChEMBL: ID CHEMBL2371246

ChemSpider: ID 30846458

PubChem: CID 73350152

ZINC: ID ZINC000013805216