BIOPEP-UWM: Report

ID 10767
Name Inhibitor of tripeptidyl peptidase II
sequence
{[ph]C1!}V{Nva}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 306.3989 Monoisotopic mass 306.1937
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1=CC=CC=C1CN[C@@]([H])(C(C)C)C(=O)N[C@@H](CCC)C(=O)O

InChI=1S/C17H26N2O3/c1-4-8-14(17(21)22)19-16(20)15(12(2)3)18-11-13-9-6-5-7-10-13/h5-7,9-10,12,14-15,18H,4,8,11H2,1-3H3,(H,19,20)(H,21,22)/t14-,15-/m0/s1

InChIKey=QBBBNVSEILDMQA-GJZGRUSLSA-N


{[ph]C1!} - N-terminal benzyl group (ID 238 in the BIOPEP-UWM repository of amino acids and modifications)
{Nva} - Norvaline (ID 230 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand PhCH2-Val-Nvl-OH

ChEMBL: ID CHEMBL2371259

ChemSpider: ID 8885145

PubChem: CID 10709804

ZINC: ID ZINC000013805200