BIOPEP-UWM: Report

ID 10786
Name Antidiabetic peptide
sequence
IRW
Function:
Peptide improving glucose tolerance in mice
 
Number of residues
3
Activity code
adb
Activity :
antidiabetic
Chemical mass 473.5671 Monoisotopic mass 473.2743
EC50 :
0.00 µM


Bibliographic data:
Authors
de Campos Zani S. C., Son M., Bhullar K. S., Chan C. B., Wu J.
Title
IRW (Isoleucine–Arginine–Tryptophan) improves glucose tolerance in high fat diet fed C57BL/6 mice via activation of insulin signaling and AMPK pathways in skeletal muscle. Biomedicines, 10, 1235, 2022
Year Source
2022 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)O

InChI=1S/C23H35N7O4/c1-3-13(2)19(24)21(32)29-17(9-6-10-27-23(25)26)20(31)30-18(22(33)34)11-14-12-28-16-8-5-4-7-15(14)16/h4-5,7-8,12-13,17-19,28H,3,6,9-11,24H2,1-2H3,(H,29,32)(H,30,31)(H,33,34)(H4,25,26,27)/t13-,17-,18-,19-/m0/s1

InChIKey=ZXJFURYTPZMUNY-VKOGCVSHSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database; the BIOPEP-UWM database of bioactive peptides (ID 9874); the DFBP database; the EROP-Moscow database
Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8213)
Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9875)
Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9876)
Activator of Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides (ID 9877)


Database reference:
AHTPDB: ID 1938, 2041, 2211

BioPepDB: ID biopep00589

BIOPEP-UWM database of bioactive peptides: ID 8213; 9874; 9875; 9876; 9877
DFBP: ID DFBPACEI0140; DFBPANOX0782; DFBPMUFU0057

EROP-Moscow: ID E23666

FeptideDB: ID 8213

PubChem: CID: 46912244

SATPdb: ID satpdb10670