BIOPEP-UWM: Report

ID 10801
Name Inhibitor of tripeptidyl peptidase II
sequence
V{G[2!ph]}{~!C1}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 263.3346 Monoisotopic mass 263.1629
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](C1=CC=CC=C1)C(=O)NC

InChI=1S/C14H21N3O2/c1-9(2)11(15)13(18)17-12(14(19)16-3)10-7-5-4-6-8-10/h4-9,11-12H,15H2,1-3H3,(H,16,19)(H,17,18)/t11-,12-/m0/s1

InChIKey=FRSBTKXVCXKMAQ-RYUDHWBXSA-N


{G[2!ph]} - Phenylglycine (ID 234 in the BIOPEP-UWM repository of amino acids and modifications)
{~!C1} - Aminomethane as a part of C-terminal amide group (ID 131 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-phenylglycine-NHCH3

ChEMBL: ID CHEMBL2371231

ChemSpider: ID 30846459

PubChem: CID: 12968184

ZINC: ID ZINC000013805186