BIOPEP-UWM: Report

ID 10802
Name Inhibitor of tripeptidyl peptidase II
sequence
VF{!OC1}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 278.3459 Monoisotopic mass 278.1625
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)OC

InChI=1S/C15H22N2O3/c1-10(2)13(16)14(18)17-12(15(19)20-3)9-11-7-5-4-6-8-11/h4-8,10,12-13H,9,16H2,1-3H3,(H,17,18)/t12-,13-/m0/s1

InChIKey=PNTFVRVSDUIVFM-STQMWFEESA-N


{!C1} - C-terminal methanol (ID 233 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Phe-OCH3

ChEMBL: ID CHEMBL2371234

ChemSpider: ID 9304743

J-Global: ID 200907028305333893

Nikkaji: ID J975.453I

PubChem: CID: 11129623

SureChEMBL: ID SCHEMBL7145259