BIOPEP-UWM: Report

ID 10803
Name Inhibitor of tripeptidyl peptidase II
sequence
{[ph]C1!}{H2CO3}V{Nle}{!OC4:0}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
5
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 420.5409 Monoisotopic mass 420.2615
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: C1=CC=CC=C1COC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)OCCCC

InChI=1S/C23H36N2O5/c1-5-7-14-19(22(27)29-15-8-6-2)24-21(26)20(17(3)4)25-23(28)30-16-18-12-10-9-11-13-18/h9-13,17,19-20H,5-8,14-16H2,1-4H3,(H,24,26)(H,25,28)/t19-,20-/m0/s1

InChIKey=VESDDTHMRCVBTQ-PMACEKPBSA-N


{[ph]C1!} - Phenylmethanol as a precursor of N-terminal group (ID 238 in the BIOPEP-UWM repository of amino acids and modifications)
{H2CO3} - Carbonic acid (ID 228 in the BIOPEP-UWM repository of amino acids and modifications)
{Nle} - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)
{!OC4:0} - C-terminal butan-1-ol (ID 236 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand PhCH2OCO-Val-Nle-O(CH2)3CH3

ChemSpider: ID 8677638

PubChem: CID 10502237