BIOPEP-UWM: Report

ID 10826
Name ACE inhibitor
sequence
HDWWKER

Function:
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
 
Number of residues
7
Activity code
ah
Activity :
ACE inhibitor
Chemical mass 1056.1311 Monoisotopic mass 1055.4923
IC50 :
583.60 µM



Bibliographic data:
Authors
Wang Y., Chen S., Shi W., Liu S., Chen X., Pan N., Wang X., Su Y., Liu Z.
Title
Targeted affinity purification and mechanism of action of angiotensin-converting enzyme (ACE) inhibitory peptides from sea cucumber gonads. Mar. Drugs, 22, 90, 2024
Year Source
2024 Journal



Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O

InChI=1S/C49H65N15O12/c50-16-6-5-12-34(43(70)60-35(14-15-40(65)66)44(71)61-36(48(75)76)13-7-17-55-49(52)53)59-45(72)37(18-26-22-56-32-10-3-1-8-29(26)32)63-46(73)38(19-27-23-57-33-11-4-2-9-30(27)33)64-47(74)39(21-41(67)68)62-42(69)31(51)20-28-24-54-25-58-28/h1-4,8-11,22-25,31,34-39,56-57H,5-7,12-21,50-51H2,(H,54,58)(H,59,72)(H,60,70)(H,61,71)(H,62,69)(H,63,73)(H,64,74)(H,65,66)(H,67,68)(H,75,76)(H4,52,53,55)/t31-,34-,35-,36-,37-,38-,39-/m0/s1

InChIKey=ZTQKWQQUTSAHJR-QOOAZBNCSA-N



Database reference: