BIOPEP-UWM: Report

ID 10837
Name Inhibitor of tripeptidyl peptidase II
sequence
V{A[3!cC6:0]}{~!C4:0}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 325.4880 Monoisotopic mass 325.2721
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1CCC(CC1))C(=O)NCCCC

InChI=1S/C18H35N3O2/c1-4-5-11-20-17(22)15(12-14-9-7-6-8-10-14)21-18(23)16(19)13(2)3/h13-16H,4-12,19H2,1-3H3,(H,20,22)(H,21,23)/t15-,16-/m0/s1

InChIKey=ZTVNDFOOMBMSCA-HOTGVXAUSA-N


{A[3!cC6:0]} - Cyclohexylalanine (ID 241 in the BIOPEP-UWM repository of amino acids and modifications)
{~!C4:0} - 1-Aminobutane as a part of C-terminal amide group (ID 235 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-(S)-cyclohexylalanyl-NH(CH2)3CH3

ChEMBL: ID CHEMBL2371271

Pubchem: CID 10758455