BIOPEP-UWM: Report

ID 10838
Name Inhibitor of tripeptidyl peptidase II
sequence
V{A[3!cC6:0]}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
2
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 270.3668 Monoisotopic mass 270.1937
IC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1CCC(CC1))C(=O)O

InChI=1S/C14H26N2O3/c1-9(2)12(15)13(17)16-11(14(18)19)8-10-6-4-3-5-7-10/h9-12H,3-8,15H2,1-2H3,(H,16,17)(H,18,19)/t11-,12-/m0/s1

InChIKey=ZRHYCGMQPVCRJZ-RYUDHWBXSA-N


{A[3!cC6:0]} - Cyclohexylalanine (ID 241 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-(S)-cyclohexylalanyl-OH

ChEMBL: ID CHEMBL2371268

ChemSpider: ID 8811129

Pubchem: CID 10635767

ZINC: ID ZINC13805255