BIOPEP-UWM: Report

ID 10840
Name Inhibitor of tripeptidyl peptidase II
sequence
V{Nle}{~!C4:0}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 285.4243 Monoisotopic mass 285.2409
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)NCCCC

InChI=1S/C15H31N3O2/c1-5-7-9-12(14(19)17-10-8-6-2)18-15(20)13(16)11(3)4/h11-13H,5-10,16H2,1-4H3,(H,17,19)(H,18,20)/t12-,13-/m0/s1

InChIKey=CPBYJJJWBFTZJW-STQMWFEESA-N


<Nle> - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)
<~!C4:0> - 1-Aminobutan as a part of C-terminal amide group (ID 235 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Nle-NH(CH2)3CH3

ChEMBL: ID CHEMBL2371251

ChemSpider: ID 8812267

PubChem: CID 10636905

ZINC: ID ZINC13805229