BIOPEP-UWM: Report

ID 10841
Name Inhibitor of tripeptidyl peptidase II
sequence
V{Nle}{~!C3:0[3ph]}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 347.4936 Monoisotopic mass 347.2565
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)NCCCC1=C-C=C-C=C1

InChI=1S/C20H33N3O2/c1-4-5-13-17(23-20(25)18(21)15(2)3)19(24)22-14-9-12-16-10-7-6-8-11-16/h6-8,10-11,15,17-18H,4-5,9,12-14,21H2,1-3H3,(H,22,24)(H,23,25)/t17-,18-/m0/s1

InChIKey=OGROYLSSMWEENY-ROUUACIJSA-N


<Nle> - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)
<~!C3:0[3ph]> - 3-Phenylpropan-1-amine as a part of C-terminal amide group (ID 244 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Nle-NH(CH2)3Ph

ChEMBL: ID CHEMBL3143509

ChemSpider: ID 8697024

PubChem: CID 10521626

ZINC: ID ZINC000013805232