BIOPEP-UWM: Report

ID 10842
Name Inhibitor of tripeptidyl peptidase II
sequence
V{Nle}{!OC4:0}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 286.4091 Monoisotopic mass 286.2249
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CCCC)C(=O)OCCCC

InChI=1S/C15H30N2O3/c1-5-7-9-12(15(19)20-10-8-6-2)17-14(18)13(16)11(3)4/h11-13H,5-10,16H2,1-4H3,(H,17,18)/t12-,13-/m0/s1

InChIKey=HHGNRJJOBWQNAS-STQMWFEESA-N


<Nle> - Norleucine (ID 231 in the BIOPEP-UWM repository of amino acids and modifications)
<!OC4:0> - C-terminal butan-1-ol (ID 236 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Nle-O(CH2)3CH3

ChEMBL: ID CHEMBL3039992

ChemSpider: ID 8907312

PubChem: CID 10731979

ZINC: ID ZINC000013805219