BIOPEP-UWM: Report

ID 10843
Name Inhibitor of tripeptidyl peptidase II
sequence
V{A[3!βnph]}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
2
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 314.3780 Monoisotopic mass 314.1625
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC1=CC2=C(C=CC=C2)C=C1)C(=O)O

InChI=1S/C18H22N2O3/c1-11(2)16(19)17(21)20-15(18(22)23)10-12-7-8-13-5-3-4-6-14(13)9-12/h3-9,11,15-16H,10,19H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-/m0/s1

InChIKey=TZMPMORBGNAGGL-HOTGVXAUSA-N


<A[3!βnph]> - 3-(2-Naphthyl)-L-alanine (ID 245 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-(beta-naphthyl)Ala-OH

ChEMBL: ID CHEMBL2371270

ChemSpider: ID 8766740

PubChem: CID 10591366

ZINC: ID ZINC000013805191