BIOPEP-UWM: Report

ID 10846
Name Inhibitor of tripeptidyl peptidase II
sequence
VF{~!C2:0}
Function:
Inhibitor of tripeptidyl peptidase II (EC 3.4.14.10) (MEROPS ID: S08.090)
 
Number of residues
3
Activity code
tpp2
Activity :
inhibitor of tripeptidyl peptidase II
Chemical mass 291.3876 Monoisotopic mass 291.1941
EC50 :
0.00 µM


Bibliographic data:
Authors
Ganellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F
Title
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000
Year Source
2000 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)NCC

InChI=1S/C16H25N3O2/c1-4-18-15(20)13(10-12-8-6-5-7-9-12)19-16(21)14(17)11(2)3/h5-9,11,13-14H,4,10,17H2,1-3H3,(H,18,20)(H,19,21)/t13-,14-/m0/s1

InChIKey=SBAGZUDPHPUWJB-KBPBESRZSA-N


<~!C2:0> - Aminoethane as a part of C-terminal amide group (ID 243 in the BIOPEP-UWM repository of amino acids and modifications)


Database reference:
BRENDA: Ligand Val-Phe-NH(CH2)CH3