BIOPEP-UWM: Report

ID 10860
Name Inhibitor of endothelin-1 release
sequence
ALPMHIR
Function:
Inhibitor of endothelin-1 release in cell culture
 
Number of residues
7
Activity code
ien1
Activity :
Inhibitor of endothelin-1 release
Chemical mass 837.0432 Monoisotopic mass 836.4677
EC50 :
0.00 µM


Bibliographic data:
Authors
Maes W., Van Camp J., Vermeirssen V., Hemeryck M., Ketelslegers J. M., Schrezenmeir J., Van Oostveldt P., Huyghebaert A.
Title
Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells. Regulatory Peptides, 118, 105–109, 2004
Year Source
2024 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides

SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC1=CN=CN1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O

InChI=1S/C37H64N12O8S/c1-7-21(4)29(34(54)45-25(36(56)57)10-8-13-42-37(39)40)48-32(52)26(17-23-18-41-19-43-23)46-31(51)24(12-15-58-6)44-33(53)28-11-9-14-49(28)35(55)27(16-20(2)3)47-30(50)22(5)38/h18-22,24-29H,7-17,38H2,1-6H3,(H,41,43)(H,44,53)(H,45,54)(H,46,51)(H,47,50)(H,48,52)(H,56,57)(H4,39,40,42)/t21-,22-,24-,25-,26-,27-,28-,29-/m0/s1

InChIKey=ZPQOMIXBBOSUPU-PNZHTLIDSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides; the DFBP database; the MBPDB database; the Peptipedia database
Immunomodulating peptide according to the BIOPEP-UWM database of bioactive peptides, the MBPDB database

Predicted ligand of SARS-CoV-2 parent protease (EC 3.4.22.69) (MEROPS ID: C30.007) (PDB: 6M03 and PDB: 6LU7) according to the BIOPEP-UWM Virtual database (ID 25)


Database reference:
AHTPDB: ID 1122, 1322, 2417, 3676, 3736, 3778, 4266, 4328, 5858

BioPepDB: ID biopep00053

BIOPEP-UWM database of bioactive peptides: ID 3261

BIOPEP-UWM Virtual: ID 25

DFBP: ID DFBPACEI0028; DFBPACEI0288

EROP-Moscow: ID E02856

FeptideDB: ID 3261

J-GLOBAL: ID 200907074317118850

MBPDB: Peptide ALPMHIR

MeSH: terms lactokinin; ALPMHIR; ALPMHIR peptide

Nikkaji: ID J812.290C

PepBank: Peptide ALPMHIR

Peptipedia: ID 482

PubChem: CID 9988076

SATPdb: ID satpdb21866

UniChem: compound ZPQOMIXBBOSUPU-PNZHTLIDSA-N

ZINC: ID ZINC000195864225