BIOPEP-UWM: Report

ID 10868
Name Cyclooxygenase-2 inhibitor
sequence
IKW
Function:
Inhibitor of cyclooxygenase-2 (EC 1.14.99.1)
 
Number of residues
3
Activity code
cox2
Activity :
cyclooxygenase-2 inhibitor
Chemical mass 445.5537 Monoisotopic mass 445.2681
EC50 :
0.00 µM


Bibliographic data:
Authors
Wang Z., Rivas-Serna I. M., Monirujjaman, Fernando I. P. S., Mazurak V. C., Wu J.
Title
Anti-inflammatory and antioxidative effects of bioactive peptides IKW and RIY in spontaneously hypertensive rats and angiotensin II-stimulated vascular smooth muscle cells. Food Biosci., 62, 105417, 2024
Year Source
2024 Journal


Additional information:
BIOPEP-UWM database of bioactive peptides


SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O

InChI=1S/C23H35N5O4/c1-3-14(2)20(25)22(30)27-18(10-6-7-11-24)21(29)28-19(23(31)32)12-15-13-26-17-9-5-4-8-16(15)17/h4-5,8-9,13-14,18-20,26H,3,6-7,10-12,24-25H2,1-2H3,(H,27,30)(H,28,29)(H,31,32)/t14-,18-,19-,20-/m0/s1

InChIKey=CEPIAEUVRKGPGP-DSYPUSFNSA-N


Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTDB database; BIOPEP-UWM database of bioactive peptides; the BRENDA database; the DFBP database; the EROP-Moscow database
Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BIOPEP-UWM database of bioactive peptides (ID 10682)


Database reference:
AHTPDB: ID 1598, 1652, 2021, 2599, 2855, 2859, 2894, 3767, 4202, 4975, 5061, 5718, 6532

BIOEP-UWM database of bioactive peptides: ID 7546; 10682

BRENDA: Ligand Ile-Lys-Trp

ChEBI: ID 158604

ChemSpider: ID 8000528

DFBP: ID DFBPACEI0090; DFBPANHY0514; DFBPMUFU0042

EROP-Moscow: ID E09190

J-Global: ID 200907057574999709

Metabolomics Workbench: ID 82893

Nikkaji: ID J1.356.192C

PubChem: CID 9824781

SATPdb: ID satpdb19180